Ep 106 – Troy Duell – How the MTHFR Mutation and Proper Supplementation Impact Fertility

Last updated Sep 19, 2022 | 0 comments

In episode #106 Troy shares his expertise as the founder of a pharmaceutical company and his personal story experiencing infertility with his wife.

Troy has always been interested in health research, and he discovered the MTHFR mutation issue in 2010. He began a deep dive into this issue as it relates to fertility and pregnancy, and he was amazed by how many people are affected. With the right tests, it was discovered that his wife had the MTHFR mutation. Proper supplementation allowed her to get pregnant and they were able to have their second child.

We discuss the difference between folic acid and folate, how the MTHFR mutation affects fertility and pregnancy, and how proper folate supplementation can make a big difference.

References are listed below, and Troy is offering a discount code for your first bottle of prenatal vitamins from his company, Centurion Labs.

Topics Discussed: infertility, folic acid, folate, MTHFR mutation, prenatal vitamins

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Scaglione, F., Panzavolta, G., Folate, Folic Acid and 5-methyltetrahydrofolate are not the same thing, Xenobiotica. Feb. 2014

Servy, Edouard, et.al., MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs. folic acid: a key to pregnancy outcome: a case series. Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-018-1225-2

Greenberg, J. Multivitamin Supplementation During Pregnancy: Emphasis on Folic Acid and L-Methylfolate. Reviews in Obstetrics & Gynecology. 2011, Vol. 4 pg 126-127.

D’Elia, PQ., et.al., MTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women. Reproductive Biomedicine Online 2014 Jun;28(6):733-8. doi: 10.1016/j.rbmo.2014.02.005.

Naqvi, H., et.al., Role of 677C® T polymorphisms a single substitution in methylenetetrahydrofolate reductase (MTHFR) gene in North Indian infertile men. Molecular Biology Reports. Feb. 2014; 41(2):573-9.

Mfady, DS, et. al., Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population. Gene. 2014 Feb 15;536(1):40-4. doi: 10.1016/j.gene.2013.12.001.

Gava, MM, et.al., Polymorphisms in folate-related enzyme genes in idiopathic infertile Brazilian men. Reproductive Sciences 2011 Dec;18(12):1267-72. doi: 10.1177/1933719111411729.

Shen, O., et.al., Association of the Methylenetetrahydrofolate Reductase Gene A1298C Polymorphism with Male Infertility: A Meta-Analysis

Updated Estimates of Neural Tube Defects Prevented by Mandatory Folic Acid Fortification, Centers for Disease Control (CDC): Morbidity and Mortality Weekly Report (MMWR), January 16, 2015.

McGowan, E., et.al., Association Between Folate Metabolites and the Development of Food Allergy in Children. Journal of Allergy and Clinical Immunology. January 2020; 8(1):132-140.

McStay, Catrina, Maternal Folic Acid Supplementation during Pregnancy and Childhood Allergic Disease Outcomes: A Question of Timing. Nutrients. 2017 February.

Wang, T., et. al., Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?, Allergy, Asthma & Immunology Research. 2015 November; 7(6): 538-546.

Whitrow, Melissa, et. al., Effect of Supplementatl Folic Acid in Pregnancy on Childhood Asthma: A Prospective Birth Cohort Study. American Journal of Epidemiology. October 2009. Vol. 170, No. 12.


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